Drug Prices Down, Biotech Profits Up? Here’s the Trade – 5/13

How to Trade President Trump’s Drug Cost Reduction Order

President Donald Trump is once again turning the spotlight on high drug prices, and the market is taking notice. In a bold move aimed at aligning U.S. medication costs with those of other developed countries, Trump is expected to sign an executive order demanding that pharmaceutical companies lower their drug prices.

This announcement is part of a broader effort to tackle one of the most controversial and costly aspects of the American healthcare system: prescription drug prices. According to a recent Reuters report, “White House officials said the government will give drug makers price targets in the next 30 days and will take further action to lower prices if those companies do not make significant progress towards those goals within six months of the order being signed.”

While such headlines typically strike fear into the hearts of pharmaceutical investors, the initial market reaction—though negative—quickly reversed. Many drug stocks that dipped on the news bounced back as analysts and traders took a closer look at the details.

Why the Market Reversed Course

At first glance, Trump’s plan appears to be a major threat to the pharmaceutical industry. For years, U.S. drug prices have been significantly higher than in countries like Canada, Germany, and the U.K., largely due to a complex web of middlemen, opaque pricing structures, and the lack of government negotiation power.

However, a closer reading of the order suggests that this may not be the disaster for drugmakers that many feared.

According to Barron’s, “It looks like it could be a blessing in disguise for drug makers, fundamentally restructuring the U.S. drug industry in a way that hurts pharmacy benefit managers.” These benefit managers, often referred to as PBMs, act as intermediaries between drug manufacturers, insurance companies, and pharmacies. Over the years, they’ve been accused of driving up costs through convoluted rebate systems and lack of transparency.

Trump’s executive order appears to shift the focus toward the direct-to-consumer market. This could end up bypassing pharmacy benefit managers entirely, allowing drug companies to sell directly to consumers or through more streamlined channels. That, in turn, could mean more pricing power and better margins for the pharmaceutical firms themselves.

In fact, many drug companies have already spent millions of dollars lobbying against PBMs and advocating for a system that puts more power back in their hands. So while the executive order sounds like a clampdown, it may actually further a goal that many pharmaceutical companies already support.

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What This Means for Investors

The immediate reaction to any presidential directive—especially one involving regulation—can create dramatic short-term volatility in stocks. But for savvy investors, these moments often present opportunities rather than threats.

There are two ways to trade this development: individual drug stocks or diversified biotech exchange-traded funds (ETFs). For those seeking lower risk and broader exposure, ETFs may offer the better play.

Here are three top ETFs to consider:

ETF: iShares Biotechnology ETF (SYM: IBB)
Expense Ratio: 0.45%
Top Holdings: Vertex Pharmaceuticals, Amgen, Gilead Sciences, Regeneron Pharmaceuticals, Alnylam Pharmaceuticals

The IBB is one of the most well-known biotech ETFs and offers exposure to a wide range of U.S.-based biotechnology companies. Its focus is on established industry leaders with strong pipelines and revenues, making it a relatively safer bet in the biotech world.

This fund is ideal for investors who want to benefit from the long-term growth of the biotech sector, regardless of short-term political noise. Many of the fund’s top holdings have the resources and regulatory savvy to adapt quickly to new rules, such as those stemming from Trump’s directive.

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ETF: iShares Biotechnology ETF (SYM: IBB)
Expense Ratio: 0.95%
Top Holdings: Vertex Pharmaceuticals, Amgen, Gilead Sciences, Regeneron Pharmaceuticals

For more aggressive investors, BIB offers a leveraged approach, aiming to deliver twice the daily performance of the Nasdaq Biotechnology Index. This means you could see amplified gains if the sector rallies in response to Trump’s drug pricing reforms.

However, it’s important to note that leveraged ETFs like BIB are best used for short-term trading rather than long-term holding. They are more volatile and can decline quickly if the sector takes a turn for the worse.

Still, if you believe the pharmaceutical industry will benefit in the near term as the new order weakens PBMs and potentially boosts drugmaker margins, BIB is a powerful tool to express that view.

ETF: SPDR S&P Biotech ETF (SYM: XBI)
Expense Ratio: 0.35%
Top Holdings: Exact Sciences, Natera Inc., United Therapeutics, Incyte Corp., AbbVie Inc.

XBI provides exposure to smaller and mid-cap biotech firms, many of which are on the cutting edge of innovation. Unlike IBB, which is weighted by market cap, XBI uses an equal-weight methodology. This means each holding has a similar impact on performance, which can help diversify risk and amplify returns from smaller players.

This ETF is great for investors who believe that policy changes like this could level the playing field and open up new distribution or pricing models that benefit smaller firms.

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